TargetMol

FzM1.8

Product Code:
 
TAR-T15363
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15363-1mg1mg£101.00
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TAR-T15363-2mg2mg£114.00
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TAR-T15363-5mg5mg£141.00
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TAR-T15363-10mg10mg£182.00
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TAR-T15363-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T15363-25mg25mg£303.00
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Quantity:
TAR-T15363-50mg50mg£502.00
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TAR-T15363-100mg100mg£662.00
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Quantity:
TAR-T15363-500mg500mg£1,299.00
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Further Information

Bioactivity:
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway.
CAS:
2204290-85-5
Formula:
C18H14N2O4
Molecular Weight:
322.31
Pathway:
Stem Cells; Cytoskeletal Signaling
Purity:
1
SMILES:
O=C(O)C=1C=C(O)C=C(C1)NC(=O)NC=2C=CC=3C=CC=CC3C2
Target:
Wnt/beta-catenin

References

Riccio G, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.