TargetMol

EN460

Product Code:
 
TAR-T15218
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
EN460 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) and interacts selectively (IC50: 1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.
CAS:
496807-64-8
Formula:
C22H12ClF3N2O4
Molecular Weight:
460.79
Purity:
0.98
SMILES:
OC(=O)c1cc(ccc1Cl)N1N=C(C(=Cc2ccc(o2)-c2ccccc2)C1=O)C(F)(F)F

References

1. Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.