TargetMol

Zatebradine hydrochloride

Product Code:
 
TAR-T13387L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13387L-1mg1mg£97.00
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TAR-T13387L-5mg5mg£131.00
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TAR-T13387L-1mL1 mL * 10 mM (in DMSO)£137.00
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TAR-T13387L-10mg10mg£166.00
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TAR-T13387L-25mg25mg£282.00
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TAR-T13387L-50mg50mg£484.00
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TAR-T13387L-100mg100mg£683.00
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TAR-T13387L-500mg500mg£1,315.00
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Further Information

Bioactivity:
Zatebradine is an effective inhibitor of hyperpolarization-activated cyclic nucleotide-gated channels (IC50: 1.96 μM). Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3, and HCN4 channels (IC50: 1.83 μM, 2.21 μM, 1.90 μM, and 1.88 μM, respectively).
CAS:
91940-87-3
Formula:
C26H37ClN2O5
Molecular Weight:
493.04
Pathway:
Membrane transporter/Ion channel|Others
Purity:
0.98
SMILES:
Cl.COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Target:
Others|HCN Channel

References

Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006;69(4):1328-37. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003;478(2-3):161-71.