TargetMol

SB-277011 dihydrochloride

Product Code:
 
TAR-T12861L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12861L-5mg5mg£850.00
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Quantity:
TAR-T12861L-50mg50mg£1,661.00
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Quantity:
TAR-T12861L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
CAS:
1226917-67-4
Formula:
C28H32Cl2N4O
Molecular Weight:
511.49
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
Cl.Cl.O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12
Target:
Dopamine Receptor

References

1. Stemp G, et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem. 2000 May 4;43(9):1878-85.