TargetMol

DMCM hydrochloride

Product Code:
 
TAR-T11061
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11061-1mg1mg£103.00
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TAR-T11061-5mg5mg£148.00
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TAR-T11061-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T11061-10mg10mg£189.00
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TAR-T11061-25mg25mg£333.00
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TAR-T11061-50mg50mg£550.00
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TAR-T11061-100mg100mg£755.00
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Further Information

Bioactivity:
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA zaerxep3 receptor subtypes. For sp1, sp2, sp3 and sp5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM
CAS:
1215833-62-7
Formula:
C17H19ClN2O4
Molecular Weight:
350.8
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.98
SMILES:
Cl.CCc1c(ncc2[nH]c3cc(OC)c(OC)cc3c12)C(=O)OC
Target:
GABA Receptor

References

1. Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32. 2. Lepp? E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.