TargetMol

Benzthiazide

Product Code:
 
TAR-T0782
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0782-100mg100mg£102.00
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Quantity:
TAR-T0782-1mL1 mL * 10 mM (in DMSO)£105.00
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Further Information

Bioactivity:
Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
CAS:
91-33-8
Formula:
C15H14ClN3O4S3
Molecular Weight:
431.92
Pathway:
Metabolism
Purity:
0.9979
SMILES:
NS(=O)(=O)c1cc2c(NC(CSCc3ccccc3)=NS2(=O)=O)cc1Cl
Target:
Carbonic Anhydrase

References

1. Temperini C, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21.