TargetMol

7ACC1

Product Code:
 
TAR-T5845
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5845-50mg50mg£107.00
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TAR-T5845-100mg100mg£124.00
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TAR-T5845-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T5845-200mg200mg£168.00
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This product comes from: United States.
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Further Information

Bioactivity:
7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
CAS:
50995-74-9
Formula:
C14H15NO4
Molecular Weight:
261.277
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
CCN(CC)c1ccc2cc(C(O)=O)c(=O)oc2c1
Target:
Monocarboxylate transporter

References

Draoui N , Schicke O , Seront E , et al. Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux[J]. Molecular Cancer Therapeutics, 2014, 13(6):1410-1418.