TargetMol

CAY10561

Product Code:
 
TAR-T36672
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36672-5mg5mg£930.00
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Quantity:
TAR-T36672-50mg50mg£1,821.00
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Quantity:
TAR-T36672-100mg100mg£2,319.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
CAS:
933786-58-4
Formula:
C22H17Cl2FN4O2
Molecular Weight:
459.3
Purity:
0.98
SMILES:
[H]N1C(C2=CNC(C(NC(CO)C3=CC=C(F)C(Cl)=C3)=O)=C2)=C(C4=CC(Cl)=CC=C4)C=N1