TargetMol

Neospiramycin I

Product Code:
 
TAR-T36183
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36183-50mg50mg£1,198.00
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Further Information

Bioactivity:
Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg).2
CAS:
70253-62-2
Formula:
C36H62N2O11
Molecular Weight:
698.9
Purity:
0.98
SMILES:
O=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)OO=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)O

References

Sano, H., Inoue, M., and ?mura, S.Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4?-deoxy derivatives of neospiramycin I and their 12-(Z)-isomersJ. Antibiot. (Tokyo)37(7)738-749(1984) Sano, H., Inoue, M., Yamashita, K., et al.Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin IJ. Antibiot. (Tokyo)36(10)1336-1344(1983)