TargetMol

AZ 5704

Product Code:
 
TAR-T35942
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35942-5mg5mg£1,171.00
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TAR-T35942-50mg50mg£2,303.00
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Quantity:
TAR-T35942-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.
CAS:
1941214-06-7
Formula:
C23H23FN6O2
Molecular Weight:
434.47
Purity:
0.98
SMILES:
COCC1=NC=C(C2=CC3=C(N=CC(C(N)=O)=C3N[C@H](C4=NN(C=C4)C)C)C=C2F)C=C1

References

Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 59 6281 PMID:27259031