TargetMol

Hydroorotic acid

Product Code:
 
TAR-T32116
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T32116-50mg50mg£304.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Hydroorotic acid, a derivative of orotic acid, can be used as an intermediate in pyrimidine biosynthesis.
CAS:
155-54-4
Formula:
C5H6N2O4
Molecular Weight:
158.113
Purity:
0.98
SMILES:
OC(=O)C1CC(=O)NC(=O)N1

References

1. Tiwari K, Kumar R, Dubey VK. Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition. Biochimie. 2016 Dec;131:45-53. doi: 10.1016/j.biochi.2016.09.009. Epub 2016 Sep 17. PubMed PMID: 27650727. 2. Duley JA, Henman MG, Carpenter KH, Bamshad MJ, Marshall GA, Ooi CY, Wilcken B, Pinner JR. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine. Mol Genet Metab. 2016 Sep;119(1-2):83-90. doi: 10.1016/j.ymgme.2016.06.008. Epub 2016 Jun 14. PubMed PMID: 27370710. 3. Alves CN, Silva JR, Roitberg AE. Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study. Phys Chem Chem Phys. 2015 Jul 21;17(27):17790-6. doi: 10.1039/c5cp02016f. Epub 2015 Jun 19. PubMed PMID: 26087682. 4. Peng WF, Huang CY. Allantoinase and dihydroorotase binding and inhibition by flavonols and the substrates of cyclic amidohydrolases. Biochimie. 2014 Jun;101:113-22. doi: 10.1016/j.biochi.2014.01.001. Epub 2014 Jan 10. PubMed PMID: 24418229.