TargetMol

Eeyarestatin I

Product Code:
 
TAR-T27240
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27240-5mg5mg£189.00
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TAR-T27240-50mg50mg£577.00
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TAR-T27240-100mg100mg£839.00
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This product comes from: United States.
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Further Information

Bioactivity:
Eeyarestatin I, an ERAD inhibitor, preferentially inhibits membrane-bound p97 to disrupt ER homeostasis and to induce tumor cell death.
CAS:
412960-54-4
Formula:
C21H23ClN6O6
Molecular Weight:
490.9
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CN(O)C1N(C(=O)N(CC(=O)NN=CC=Cc2ccc(o2)[N+]([O-])=O)C1(C)C)c1ccc(Cl)cc1
Target:
Apoptosis

References

1. Ding R, Zhang T, Xie J, Williams J, Ye Y, Chen L. Eeyarestatin I derivatives with improved aqueous solubility. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5177-5181. doi: 10.1016/j.bmcl.2016.09.068. Epub 2016 Sep 29. PubMed PMID: 27729187. 2. Berry GE, Asokan A. Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. J Biol Chem. 2016 Jan 8;291(2):939-47. doi: 10.1074/jbc.M115.687657. Epub 2015 Nov 2. PubMed PMID: 26527686; PubMed Central PMCID: PMC4705411. 3. Meinig JM, Fu L, Peterson BR. Synthesis of Fluorophores that Target Small Molecules to the Endoplasmic Reticulum of Living Mammalian Cells. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9696-9. doi: 10.1002/anie.201504156. Epub 2015 Jun 26. PubMed PMID: 26118368; PubMed Central PMCID: PMC4539238. 4. Shah PP, Beverly LJ. Regulation of VCP/p97 demonstrates the critical balance between cell death and epithelial-mesenchymal transition (EMT) downstream of ER stress. Oncotarget. 2015 Jul 10;6(19):17725-37. PubMed PMID: 25970786; PubMed Central PMCID: PMC4627341.