TargetMol

GR-203040 HCl

Product Code:
 
TAR-T24102
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24102-5mg5mg£850.00
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TAR-T24102-50mg50mg£1,661.00
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TAR-T24102-100mg100mg£2,079.00
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Further Information

Bioactivity:
GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. GR-203040 is a selective NK1 receptor antagonist.
CAS:
168398-02-5
Formula:
C20H26Cl2N6O
Molecular Weight:
437.37
Purity:
0.98
SMILES:
Cl.Cl.COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)-n1cnnn1

References

1. Gallantine EL, Meert TF. Attenuation of the gerbil writhing response by mu-, kappa- and delta-opioids, and NK-1, -2 and -3 receptor antagonists. Pharmacol Biochem Behav. 2004 Sep;79(1):125-35. PubMed PMID: 15388292. 2. Bergstr?m M, Fasth KJ, Kilpatrick G, Ward P, Cable KM, Wipperman MD, Sutherland DR, L?ngstr?m B. Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkey. Neuropharmacology. 2000 Feb 14;39(4):664-70. PubMed PMID: 10728887. 3. Alfieri AB, Gardner CJ. Effects of GR203040, an NK1 antagonist, on radiation- and cisplatin-induced tissue damage in the ferret. Gen Pharmacol. 1998 Nov;31(5):741-6. PubMed PMID: 9809472. 4. Alfieri A, Gardner C. The NK1 antagonist GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. Gen Pharmacol. 1997 Aug;29(2):245-50. PubMed PMID: 9251907.