TargetMol

Unoprostone isopropyl

Product Code:
 
TAR-T20644
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20644-5mg5mg£1,653.00
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TAR-T20644-50mg50mg£3,267.00
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Quantity:
TAR-T20644-100mg100mg£4,488.00
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This product comes from: United States.
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Further Information

Bioactivity:
Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.
CAS:
120373-24-2
Formula:
C25H44O5
Molecular Weight:
424.622
Purity:
0.98
SMILES:
CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=C/CCCC(=O)OC(C)C

References

1. Akiyama M, Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T. Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa. Acta Ophthalmol. 2014 May;92(3):e229-34. PubMed PMID: 24868583. 2. Tanano I, Nagaoka T, Ono S, Omae T, Otani S, Yoshida A. Vasodilatory mechanisms of unoprostone isopropyl in isolated porcine retinal arterioles. Mol Vis. 2015 Jun 12;21:699-705. eCollection 2015. PubMed PMID: 26120274; PubMed Central PMCID: PMC4463970. 3. Harms NV, Toris CB. Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease. Expert Opin Pharmacother. 2013 Jan;14(1):105-13. doi: 10.1517/14656566.2013.748038. Epub 2012 Nov 30. Review. PubMed PMID: 23199345. 4. Cuppoletti J, Malinowska DH, Tewari KP, Chakrabarti J, Ueno R. Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca??]i increases in human trabecular meshwork and smooth muscle. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5178-89. doi: 10.1167/iovs.11-9046. PubMed PMID: 22786902.