TargetMol

(S,R,S)-AHPC TFA

Product Code:
 
TAR-T17927
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17927-1mg1mg£205.00
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TAR-T17927-5mg5mg£400.00
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TAR-T17927-10mg10mg£550.00
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TAR-T17927-25mg25mg£852.00
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TAR-T17927-50mg50mg£1,107.00
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TAR-T17927-100mg100mg£1,492.00
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Quantity:
TAR-T17927-500mg500mg£2,922.00
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Further Information

Bioactivity:
(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
CAS:
1631137-51-3
Formula:
C24H31F3N4O5S
Molecular Weight:
544.59
Pathway:
Others|PROTAC
Purity:
0.9799
SMILES:
OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
Target:
Others|Ligand for E3 Ligase

References

1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.