TargetMol

PF-06446846 hydrochloride

Product Code:
 
TAR-T16491
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16491-1mg1mg£144.00
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TAR-T16491-5mg5mg£252.00
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TAR-T16491-1mL1 mL * 10 mM (in DMSO)£258.00
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TAR-T16491-10mg10mg£362.00
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TAR-T16491-25mg25mg£547.00
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TAR-T16491-50mg50mg£752.00
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TAR-T16491-100mg100mg£1,010.00
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TAR-T16491-500mg500mg£1,942.00
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Further Information

Bioactivity:
PF-06446846 hydrochloride suppresses PCSK9 by inducing the ribosome to stall around codon 34. PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9.
CAS:
1632250-50-0
Formula:
C22H21Cl2N7O
Molecular Weight:
470.36
Purity:
0.98
SMILES:
Cl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12

References

1. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.