TargetMol

PF-04447943

Product Code:
 
TAR-T16478
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16478-5mg5mg£137.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T16478-1mL1 mL * 10 mM (in DMSO)£144.00
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Quantity:
TAR-T16478-10mg10mg£177.00
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Quantity:
TAR-T16478-25mg25mg£298.00
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Quantity:
TAR-T16478-50mg50mg£434.00
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Quantity:
TAR-T16478-100mg100mg£655.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PF-04447943 is an effective inhibitor of human recombinant PDE9A (IC50=12 nM). It has >78-fold selectivity, compared to other PDE family members (IC50>1000 nM).
CAS:
1082744-20-4
Formula:
C20H25N7O2
Molecular Weight:
395.467
Pathway:
Metabolism
Purity:
0.98
SMILES:
C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Target:
PDE

References

1. Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341(2):396-409. 2. Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and