TargetMol

Perzinfotel

Product Code:
 
TAR-T16473
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16473-50mg50mg£844.00
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TAR-T16473-100mg100mg£1,299.00
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Further Information

Bioactivity:
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neuroprotective effects.
CAS:
144912-63-0
Formula:
C9H13N2O5P
Molecular Weight:
260.186
Pathway:
Neuroscience
Purity:
0.98
SMILES:
OP(O)(=O)CCN1CCCNc2c1c(=O)c2=O
Target:
NMDAR

References

1. Brandt MR, et al. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther. 2005 Jun;313(3):1379-86. 2. Kinney WA, et al. Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid(EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere. J Med Chem. 1998 Jan 15;41(2):236-46.