TargetMol

Rofecoxib

Product Code:
 
TAR-T1185
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1185-50mg50mg£101.00
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Quantity:
TAR-T1185-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1185-100mg100mg£111.00
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TAR-T1185-200mg200mg£120.00
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This product comes from: United States.
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Further Information

Bioactivity:
Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
CAS:
162011-90-7
Formula:
C17H14O4S
Molecular Weight:
314.36
Pathway:
Immunology/Inflammation; Neuroscience
Purity:
0.9994
SMILES:
CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
Target:
COX

References

1. Chan CC, et al. J Pharmacol Exp Ther. 1999, 290(2), 551-560. 2. Karjalainen MJ, et al. Drug Metab Dispos. 2006, 34(12), 2091-2096. 3. Tu CT, et al. J Gastroenterol Hepatol. 2007, 22(6), 877-884.