TargetMol

Heptamidine

Product Code:
 
TAR-T11553L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11553L-5mg5mg£850.00
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TAR-T11553L-50mg50mg£1,661.00
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Quantity:
TAR-T11553L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy.
CAS:
94345-47-8
Formula:
C21H28N4O2
Molecular Weight:
368.481
Purity:
0.98
SMILES:
NC(=N)c1ccc(OCCCCCCCOc2ccc(cc2)C(N)=N)cc1

References

1. McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett.?2012?Dec 13;3(12):975-979. Epub?2012?Sep 25. 2. Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol.?2013 Nov 15;8(11):2528-37.