TargetMol

EC359

Product Code:
 
TAR-T11146
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11146-50mg50mg£1,163.00
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TAR-T11146-100mg100mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
EC359Kd, 10.2 nM, interacts directly with LIFR and effectively blocks LIF/LIFR interaction. It is a potent, selective, highly affinity, and oral active leukemia inhibitor of LIFR.
CAS:
2012591-09-0
Formula:
C36H38F2O2
Molecular Weight:
540.695
Purity:
0.98
SMILES:
[H][C@@]12CC[C@@](O)(C(F)(F)C#C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)-c1c(C)cc(C)cc1C

References

1. Viswanadhapalli S, et al. EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. 2019 Aug;18(8):1341-1354.