TargetMol

Droloxifene

Product Code:
 
TAR-T11098
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11098-1mg1mg£138.00
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TAR-T11098-5mg5mg£229.00
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TAR-T11098-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T11098-10mg10mg£309.00
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TAR-T11098-25mg25mg£485.00
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TAR-T11098-50mg50mg£662.00
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TAR-T11098-100mg100mg£863.00
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TAR-T11098-500mg500mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
Droloxifene, a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.
CAS:
82413-20-5
Formula:
C26H29NO2
Molecular Weight:
387.523
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
CCC(=C(c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1
Target:
Estrogen Receptor/ERR

References

1. Herrington DM, et al. Cardiovascular effects of droloxifene, a new selective estrogen receptor modulator, in healthypostmenopausal women. Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1606-12. 2. Grasser WA, et al. Common mechanism for the estrogen agonist and antagonist activities of droloxifene. J Cell Biochem. 1997 May;65(2):159-71. 3. Ke HZ, et al. Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. ndocrinology. 1995 Jun;136(6):2435-41. 4. Huang Y, et al. Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity. Acta Pharmacol Sin. 2005 Oct;26(10):1243-7.