TargetMol

DB1976 dihydrochloride

Product Code:
 
TAR-T10964L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10964L-5mg5mg£370.00
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TAR-T10964L-50mg50mg£1,468.00
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TAR-T10964L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
DB1976 hydrochloride is a selenium selenium analogue of DB270, a potent and permeable cell transcription factor PU.1 inhibitor. In vitro, DB1976 hydrochloride effectively inhibited PU.1 binding (IC50 of 10 nM) and strongly inhibited PU.1 / DNA complex (with high DB1976-λB affinity, KD of 12 nM). DB1976 hydrochloride has the effect of inducing apoptosis.
CAS:
2369663-93-2
Formula:
C20H18Cl2N8Se
Molecular Weight:
520.29
Purity:
0.98
SMILES:
Cl.Cl.NC(=N)c1ccc2nc([nH]c2c1)-c1ccc([se]1)-c1nc2ccc(cc2[nH]1)C(N)=N

References

1. Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90. 2. Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13. 3. Antony-Debr? I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313.