TargetMol

Cevipabulin fumarate

Product Code:
 
TAR-T10772L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).
CAS:
849550-67-0
Formula:
C22H22ClF5N6O5
Molecular Weight:
580.9
Purity:
0.98
SMILES:
OC(=O)C=CC(O)=O.CNCCCOc1cc(F)c(c(F)c1)-c1c(Cl)nc2ncnn2c1N[C@@H](C)C(F)(F)F

References

1. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. 2. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.