TargetMol

Mavorixafor trihydrochloride

Product Code:
 
TAR-T10296
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10296-50mg50mg£751.00
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Quantity:
TAR-T10296-100mg100mg£1,187.00
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This product comes from: United States.
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Further Information

Bioactivity:
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
CAS:
2309699-17-8
Formula:
C21H30Cl3N5
Molecular Weight:
458.86
Pathway:
Microbiology/Virology; Proteases/Proteasome
Purity:
0.98
SMILES:
Cl.Cl.Cl.NCCCCN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc12
Target:
HIV Protease

References

1. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88. 2. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.