TargetMol

Colchicine

Product Code:
 
TAR-T0320
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0320-100mg100mg£98.00
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Quantity:
TAR-T0320-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0320-200mg200mg£111.00
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TAR-T0320-500mg500mg£122.00
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This product comes from: United States.
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Further Information

Bioactivity:
Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
CAS:
64-86-8
Formula:
C22H25NO6
Molecular Weight:
399.443
Pathway:
Cytoskeletal Signaling; Autophagy; Apoptosis
Purity:
0.9996
SMILES:
COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Target:
Apoptosis; Microtubule Associated; Autophagy

References

1. Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200. 2. Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587. 3. Jiang W, Yang A, Ma J, et al. Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens[J]. bioRxiv. 2020 4. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling[J]. Frontiers in Immunology. 2020, 11: 3197. 5. Dong H, Sun H, Zheng J. A microchip for integrated single-cell genotoxicity assay[J]. Talanta. 2016, 161: 804-811. 7. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.