TargetMol

Bosentan

Product Code:
 
TAR-T6264
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6264-25mg25mg£112.00
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Quantity:
TAR-T6264-50mg50mg£132.00
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TAR-T6264-1mL1 mL * 10 mM (in DMSO)£137.00
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TAR-T6264-100mg100mg£176.00
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TAR-T6264-200mg200mg£246.00
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Quantity:
TAR-T6264-500mg500mg£335.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
CAS:
147536-97-8
Formula:
C27H29N5O6S
Molecular Weight:
551.62
Pathway:
GPCR/G Protein
Purity:
1
SMILES:
COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Target:
Endothelin Receptor

References

Ilsar R, et al. Eur Respir J. 2010, 36(6):1483-1485. Dhillon S, et al. Am J Cardiovasc Drugs,2009;9(5):331-50. Lepist EI, et al. PLoS One. 2014, 9(1):e87548. Iglarz M, et al. Life Sci. 2014, 118(2):333-339.