TargetMol

β-Nicotinamide mononucleotide

Product Code:
 
TAR-T4721
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4721-25mg25mg£128.00
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TAR-T4721-50mg50mg£157.00
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TAR-T4721-100mg100mg£193.00
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Further Information

Bioactivity:
Nicotinamide ribotide (NMN) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to NMN by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction NMN + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus NMN is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating NMN levels may play an important role in regulating cell function in physiological and pathophysiological conditions.
CAS:
1094-61-7
Formula:
C11H15N2O8P
Molecular Weight:
334.221
Pathway:
Metabolism;
Purity:
0.9966
SMILES:
NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Target:
Endogenous Metabolite

References

Ohdoi C, et al. Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30. Zhao S, Hong Y, Liang Y, et al. Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast. Redox biology. 2022, 55: 102414. Xu B, Zhang P, Tang X, et al. Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia?Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. Advanced Science. 2022: 2204697.