TargetMol

CXCR2-IN-2

Product Code:
 
TAR-T36923
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36923-5mg5mg£337.00
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Quantity:
TAR-T36923-50mg50mg£1,532.00
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Quantity:
TAR-T36923-100mg100mg£2,336.00
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This product comes from: United States.
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Further Information

Bioactivity:
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
CAS:
1838123-21-9
Formula:
C18H23ClN2O5S
Molecular Weight:
414.9
Purity:
0.98
SMILES:
N/A

References

Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.