TargetMol

Lu AE98134

Product Code:
 
TAR-T36813
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36813-5mg5mg£304.00
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TAR-T36813-50mg50mg£1,163.00
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TAR-T36813-100mg100mg£1,797.00
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Further Information

Bioactivity:
Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Nav1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al[1].
CAS:
849000-18-6
Formula:
C21H23N5O3S
Molecular Weight:
425.51
Purity:
0.98
SMILES:
CCCCNS(=O)(=O)c1ccc(OC)c(c1)-c1nnc2c3ccccc3c(C)nn12

References

Nadia Lyb?l von Schoubye, et al. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6 +/- mice. Neurosci Lett. 2018 Jan 1;662:29-35.