TargetMol

FD223

Product Code:
 
TAR-T35531
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35531-5mg5mg£270.00
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TAR-T35531-50mg50mg£1,026.00
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TAR-T35531-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML[1].
CAS:
2050524-24-6
Formula:
C17H12ClN5O2S
Molecular Weight:
385.83
Purity:
0.98
SMILES:
N/A

References

Yang C, et al. Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3K? inhibitor: Design, synthesis and biological evaluation [published online ahead of print, 2021 Jun 21]. Eur J Med Chem. 2021;223:113661.