TargetMol

(S)-PI3K α-IN-4

Product Code:
 
TAR-T35488
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35488-5mg5mg£337.00
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TAR-T35488-50mg50mg£1,532.00
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TAR-T35488-100mg100mg£2,079.00
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Further Information

Bioactivity:
(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer[1]. (S)-PI3Kα-IN-4 (compound 11) is a quinazolin-4(3H)-one derivative with 2-substituted-N-methylpropanamide substitution[1].
CAS:
2322293-84-3
Formula:
C25H23ClFN5O5S
Molecular Weight:
560
Purity:
0.98
SMILES:
N/A

References

Dong J, et, al. Discovery of 3-Quinazolin-4(3 H)-on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3K? Inhibitors. ACS Med Chem Lett. 2020 Jun 10;11(7):1463-1469.