TargetMol

RO5166017

Product Code:
 
TAR-T34373
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34373-5mg5mg£270.00
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Quantity:
TAR-T34373-50mg50mg£1,091.00
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Quantity:
TAR-T34373-100mg100mg£1,621.00
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This product comes from: United States.
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Further Information

Bioactivity:
RO-5166017 is an effective and selective trace amine related receptor 1 agonist, with no significant activity at other targets.
CAS:
1048346-74-2
Formula:
C12H19Cl2N3O
Molecular Weight:
292.2
Purity:
0.98
SMILES:
Cl.Cl.CCN(C[C@H]1COC(N)=N1)c1ccccc1

References

Sukhanov I, Espinoza S, Yakovlev DS, Hoener MC, Sotnikova TD, Gainetdinov RR. TAAR1-dependent effects of apomorphine in mice. Int J Neuropsychopharmacol. 2014 Oct;17(10):1683-93. doi: 10.1017/S1461145714000509. Epub 2014 Jun 13. PubMed PMID: 24925023. Alvarsson A, Zhang X, Stan TL, Schintu N, Kadkhodaei B, Millan MJ, Perlmann T, Svenningsson P. Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, l-DOPA Responsivity, and Glutamatergic Neurotransmission. J Neurosci. 2015 Oct 14;35(41):14057-69. doi: 10.1523/JNEUROSCI.1312-15.2015. PubMed PMID: 26468205. Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR. Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology. 2014 Jun;81:283-91. doi: 10.1016/j.neuropharm.2014.02.007. Epub 2014 Feb 22. PubMed PMID: 24565640. Cichero E, Espinoza S, Franchini S, Guariento S, Brasili L, Gainetdinov RR, Fossa P. Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach. Chem Biol Drug Des. 2014 Dec;84(6):712-20. doi: 10.1111/cbdd.12367. Epub 2014 Jun 30. PubMed PMID: 24894156.