TargetMol

Sephin1

Product Code:
 
TAR-T21824
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21824-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T21824-25mg25mg£124.00
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Quantity:
TAR-T21824-50mg50mg£151.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T21824-100mg100mg£192.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T21824-200mg200mg£252.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α
CAS:
13098-73-2
Formula:
C8H9ClN4
Molecular Weight:
196.64
Pathway:
Metabolism
Purity:
0.998
SMILES:
NC(=N)NN=Cc1ccccc1Cl
Target:
Phosphatase

References

1. Ruiz A , Zuazo J , Ortiz-Sanz C , et al. Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response[J]. International Journal of Molecular Sciences, 2020, 21(17):6088. 2. Das I , Krzyzosiak A , Schneider K , et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit[J]. Science, 2015, 348(6231):239-242.