TargetMol

Fulvestrant

Product Code:
 
TAR-T2146
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2146-25mg25mg£133.00
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TAR-T2146-100mg100mg£230.00
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TAR-T2146-500mg500mg£549.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
CAS:
129453-61-8
Formula:
C32H47F5O3S
Molecular Weight:
606.77
Pathway:
Endocrinology/Hormones; Autophagy; Apoptosis
Purity:
0.9987
SMILES:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31
Target:
Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy

References

1. Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991 Aug 1;51(15):3867-73. 2. Huynh H, et al. Regulation of insulin-like growth factor I receptor expression by the pure antiestrogen ICI 182780. Clin Cancer Res. 1996 Dec;2(12):2037-42. 3. Zhao L, et al. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. J Pharmacol Exp Ther. 2006 Dec;319(3):1124-32. 4. Fernandes SA, et al. The anti-oestrogen fulvestrant (ICI 182,780) reduces the androgen receptor expression, ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate. Int J Androl. 2011 Oct;34(5 Pt 1):486-500. 5. Chen D, Tan Y, Li Z, et al. Organoid cultures derived from patients with papillary thyroid cancer[J]. The Journal of Clinical Endocrinology & Metabolism. 2021, 106(5): 1410-1426. 6. Chen D, Tan Y, Li Z, et al. Organoid cultures derived from patients with papillary thyroid cancer[J]. The Journal of Clinical Endocrinology & Metabolism. 2021 7. Zhao Z, Xue F, Gu Y, et al. Crosstalk between the muscular estrogen receptor ? and BDNF/TrkB signaling alleviates metabolic syndrome via 7, 8-dihydroxyflavone in female mice[J]. Molecular Metabolism. 2020: 101149.