Cevimeline

Product Code:

TAR-T21119

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T21119-25mg

25mg

£993.00

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Quantity:

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Further Information

Bioactivity:

Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy.

CAS:

107233-08-9

Formula:

C10H17NOS

Molecular Weight:

199.31

Purity:

0.98

SMILES:

C[C@H]1O[C@]2(CS1)CN1CCC2CC1

Documents

References

1. Barbe AG. Long-term Use of the Sialogogue Medications Pilocarpine and Cevimeline Can Reduce Xerostomia Symptoms and Increase Salivary Flow in Head and Neck Cancer Survivors After Radiotherapy. J Evid Based Dent Pract. 2017 Sep;17(3):268-270. doi: 10.1016/j.jebdp.2017.06.013. Epub 2017 Jul 3. PubMed PMID: 28865825. 2. Mitoh Y, Ueda H, Ichikawa H, Fujita M, Kobashi M, Matsuo R. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7. doi: 10.1016/j.autneu.2017.05.010. Epub 2017 May 30. PubMed PMID: 28600120.