TargetMol

Loratadine specified impurity F

Product Code:
 
TAR-T20814
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20814-25mg25mg£402.00
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TAR-T20814-100mg100mg£851.00
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Further Information

Bioactivity:
Loratadine specified impurity F is a fluorinated analog of Loratadine.
CAS:
125743-80-8
Formula:
C22H24ClFN2O2
Molecular Weight:
402.89
Purity:
0.98
SMILES:
CCOC(=O)N1CCC(CC1)C1(F)c2ccc(Cl)cc2CCc2cccnc12

References

1. Patel JZ, Ahenkorah S, Vaara M, Staszewski M, Adams Y, Laitinen T, Navia-Paldanius D, Parkkari T, Savinainen JR, Walczy?ski K, Laitinen JT, Nevalainen TJ. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42. doi: 10.1016/j.bmcl.2015.02.037. Epub 2015 Feb 24. PubMed PMID: 25752982. 2. Baumann-Birkbeck L, Grant GD, Anoopkumar-Dukie S, Kavanagh JJ. Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. Clin Neurophysiol. 2014 Dec;125(12):2390-6. doi: 10.1016/j.clinph.2014.03.026. Epub 2014 Apr 12. PubMed PMID: 24791618. 3. Li W, Doherty J, Moench P, Flarakos J, Tse FL. LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1;983-984:117-24. doi: 10.1016/j.jchromb.2014.12.033. Epub 2015 Jan 13. PubMed PMID: 25645810. 4. Li H, Tan Y, Yang L, Gao L, Wang T, Yang X, Quan D. Dissolution evaluation in vitro and bioavailability in vivo of self-microemulsifying drug delivery systems for pH-sensitive drug loratadine. J Microencapsul. 2015;32(2):175-80. doi: 10.3109/02652048.2014.985340. Epub 2014 Nov 21. PubMed PMID: 25413271.