TargetMol

Voclosporin

Product Code:
 
TAR-T17235
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17235-1mg1mg£182.00
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TAR-T17235-5mg5mg£369.00
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TAR-T17235-10mg10mg£550.00
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TAR-T17235-1mL1 mL * 10 mM (in DMSO)£914.00
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TAR-T17235-25mg25mg£1,026.00
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TAR-T17235-50mg50mg£1,589.00
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Quantity:
TAR-T17235-100mg100mg£2,456.00
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This product comes from: United States.
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Further Information

Bioactivity:
Voclosporin is an inhibitor of calcineurin.
CAS:
515814-01-4
Formula:
C63H111N11O12
Molecular Weight:
1214.646
Pathway:
Metabolism
Purity:
0.98
SMILES:
[H][C@@]1(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)CC=CC=C)N(C)C(=O)[C@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C
Target:
Phosphatase

References

Arriens C, et al. Update on the Efficacy and Safety Profile of Voclosporin: An Integrated Analysis of Clinical Trials in Lupus Nephritis. Arthritis Care Res (Hoboken). 2023;75(7):1399-1408. Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22(12):1343-52. Cunningham MA, et al. LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells. Invest Ophthalmol Vis Sci. 2009;50(1):249-255. Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20(2):161. Rovin BH, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019;95(1):219-231.