TargetMol

Sabizabulin

Product Code:
 
TAR-T17228
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17228-1mg1mg£189.00
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TAR-T17228-2mg2mg£246.00
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TAR-T17228-5mg5mg£369.00
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TAR-T17228-10mg10mg£533.00
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TAR-T17228-25mg25mg£815.00
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TAR-T17228-50mg50mg£1,083.00
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TAR-T17228-100mg100mg£1,420.00
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TAR-T17228-500mg500mg£2,793.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sabizabulin is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7. Sabizabulin shows antiproliferative activity and can be used in prostate cancer studies.
CAS:
1332881-26-1
Formula:
C21H19N3O4
Molecular Weight:
377.39
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
O=C(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N2)C3=CNC=4C=CC=CC43
Target:
Microtubule Associated

References

1. Wang Q, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J Med Chem. 2019 Jul 12. 2. Qinghui Wang, et al. Discovery of ABI-231 analogs targeting the colchicine site in tubulin for advanced melanoma. Cancer Research 76(14 Supplement):4848-4848. 3. Vivek Kashyap, et al. ABI-231: A novel small molecule suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting Human papilloma virus (HPV) E6 and E7. Cancer Research 78(13 Supplement):679-679. 4. Kashyap VK, et al. Therapeutic efficacy of a novel ?III/?IV-tubulin inhibitor (VERU-111) in pancreatic cancer. J Exp Clin Cancer Res. 2019 Jan 23;38(1):29.