TargetMol

Rheb inhibitor NR1

Product Code:
 
TAR-T16741
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16741-50mg50mg£870.00
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TAR-T16741-100mg100mg£1,428.00
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Further Information

Bioactivity:
Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 is a Rheb inhibitor (IC50: 2.1 μM in the Rheb-IVK assay). NR1 also is a selective mTORC1 inhibitor.
CAS:
2216763-38-9
Formula:
C25H19BrCl2N2O3S
Molecular Weight:
578.3
Purity:
0.98
SMILES:
CN(C)C(=O)c1ccc(Cn2c(cc3c(Br)cc(Sc4ccc(Cl)c(Cl)c4)cc23)C(O)=O)cc1

References

1. Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.