TargetMol

Mcl1-IN-8

Product Code:
 
TAR-T16030
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Mcl1-IN-8 is an Mcl-1-PUMA interface inhibitor (Ki: 0.3 μM). In cancer cells, Mcl1-IN-8 shows dual activity on reducing PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis.
CAS:
678158-55-9
Formula:
C22H23N3O2S
Molecular Weight:
393.51
Purity:
0.98
SMILES:
OCCN1CCN(CC1)C1=NC(=O)C(S1)=Cc1ccc(cc1)-c1ccccc1

References

1. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.