TargetMol

IT-901

Product Code:
 
TAR-T15601
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15601-5mg5mg£304.00
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TAR-T15601-50mg50mg£1,026.00
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Quantity:
TAR-T15601-100mg100mg£1,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT-901 has the potential for human lymphoid tumors, and ameliorate graft-versus-host disease.
CAS:
1584121-99-2
Formula:
C17H14N2O4S
Molecular Weight:
342.37
Pathway:
NF-κb
Purity:
0.98
SMILES:
COc1cc(OC)c2ccccc2c1C=C1C(=O)NC(=S)NC1=O
Target:
NF-κB

References

1. Shono Y, et al. Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in HematologicMalignancies by Blocking NF-?B-Controlled Oxidative Stress Responses. Cancer Res. 2016 Jan 15;76(2):377-89. 2. Vaisitti T, et al. Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cellsby a novel NF-?B inhibitor. Haematologica. 2017 Nov;102(11):1878-1889.