TargetMol

Fidarestat

Product Code:
 
TAR-T15281
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15281-5mg5mg£241.00
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TAR-T15281-50mg50mg£870.00
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TAR-T15281-100mg100mg£1,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
CAS:
136087-85-9
Formula:
C12H10FN3O4
Molecular Weight:
279.227
Pathway:
Endocrinology/Hormones; Metabolism
Purity:
0.98
SMILES:
NC(=O)[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(F)ccc2O1
Target:
Reductase

References

1. Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. 2. Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9.