TargetMol

Curcumin

Product Code:
 
TAR-T1516
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1516-25mg25mg£95.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T1516-50mg50mg£101.00
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TAR-T1516-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1516-100mg100mg£111.00
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TAR-T1516-200mg200mg£116.00
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TAR-T1516-500mg500mg£141.00
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Further Information

Bioactivity:
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
CAS:
458-37-7
Formula:
C21H20O6
Molecular Weight:
368.39
Pathway:
Cell Cycle/Checkpoint; Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; Immunology/Inflammation; Autophagy
Purity:
0.9751
SMILES:
COc1cc(ccc1O)C=CC(=O)CC(=O)C=Cc1ccc(O)c(OC)c1
Target:
Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; Autophagy

References

1. Gao S, et al. Food Chem Toxicol. 2013, 59:739-47. 10. Tian D, Cao L, Li Q, et al. Benzannulated 5, 5-spiroketal sesquiterpenes from the roots of Angelica Pubescens[J]. Bioorganic Chemistry. 2021, 107: 104604. 2. Nasiri M, et al. Asian Pac J Cancer Prev. 2013, 14(6):3449-3453. 3. Cao A, et al. Apoptosis. 2013, 18(11):1391-1402. 4. Jiang H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 47:33-39. 5. Odot J, et al. Int J Cancer. 2004, 111(3):381-387. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 8. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin[J]. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15. 9. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/?-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.