TargetMol

A-1165442

Product Code:
 
TAR-T14067
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14067-5mg5mg£351.00
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TAR-T14067-50mg50mg£1,629.00
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Quantity:
TAR-T14067-100mg100mg£2,303.00
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This product comes from: United States.
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Further Information

Bioactivity:
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
CAS:
1221443-94-2
Formula:
C22H20ClF2N3O2
Molecular Weight:
431.87
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
Cc1cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2cn1
Target:
TRP/TRPV Channel

References

1. Voight EA, et al. Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. J Med Chem. 2014 Sep 11;57(17):7412-24.