TargetMol

DS18561882

Product Code:
 
TAR-T11103
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11103-5mg5mg£304.00
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TAR-T11103-50mg50mg£1,163.00
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Quantity:
TAR-T11103-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063.
CAS:
2227149-22-4
Formula:
C28H31F3N4O6S
Molecular Weight:
608.63
Purity:
0.98
SMILES:
C[C@H]1CN(CCN1C)c1ccc2c3CCN(Cc3c(=O)oc2c1C)C(=O)c1ccc(NS(C)(=O)=O)c(OC(F)(F)F)c1

References

1. Kawai J, et al. Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with In Vivo Anti-Tumor Activity. J Med Chem. 2019 Oct 22.