TargetMol

D-Kynurenine

Product Code:
 
TAR-T10938
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10938-25mg25mg£109.00
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Quantity:
TAR-T10938-50mg50mg£136.00
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TAR-T10938-100mg100mg£177.00
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Quantity:
TAR-T10938-200mg200mg£227.00
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This product comes from: United States.
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Further Information

Bioactivity:
D-Kynurenine is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
CAS:
13441-51-5
Formula:
C10H12N2O3
Molecular Weight:
208.217
Pathway:
Immunology/Inflammation; Endocrinology/Hormones; GPCR/G Protein; Metabolism
Purity:
0.98
SMILES:
N[C@H](CC(=O)c1ccccc1N)C(O)=O
Target:
GPR; AhR; Endogenous Metabolite

References

1. Wang XD, et al. A method for the determination of D-kynurenine in biological tissues. Anal Bioanal Chem. 2013 Dec;405(30):9747-54. 2. Irukayama-Tomobe Y, et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. 3. Kozaki A, et al. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate. Biosci Trends. 2012 Oct;6(5):241-7. 4. Duan Z, et al. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor. Mol Cell Biochem. 2018 Nov;448(1-2):165-173.