TargetMol

8-M-PDOT

Product Code:
 
TAR-T10198
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10198-50mg50mg£677.00
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Quantity:
TAR-T10198-100mg100mg£1,026.00
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This product comes from: United States.
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Further Information

Bioactivity:
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. It is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors (pKi: 8.23 and 8.95).
CAS:
134865-70-6
Formula:
C14H19NO2
Molecular Weight:
233.311
Purity:
0.98
SMILES:
CCC(=O)NC1CCc2cccc(OC)c2C1

References

1. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. 2. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54.