TargetMol

Methotrexate disodium

Product Code:
 
TAR-T8003
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8003-50mg50mg£98.00
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TAR-T8003-100mg100mg£109.00
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TAR-T8003-200mg200mg£121.00
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TAR-T8003-500mg500mg£173.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
CAS:
7413-34-5
Formula:
C20H20N8Na2O5
Molecular Weight:
498.4
Pathway:
Cell Cycle/Checkpoint; Apoptosis; DNA Damage/DNA Repair; Metabolism
Purity:
0.9977
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc1.[Na+].[Na+]
Target:
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate

References

Yang W , Zou Y , Meng F , et al. Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All-Function-in-One Chimeric Polymersomes[J]. Advanced Materials, 2016, 28(37):8234-8239. Yang W , Xia Y , Fang Y , et al. Selective Cell Penetrating Peptide-Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo[J]. Advanced Healthcare Materials, 2017:1701135.