TargetMol

T0901317

Product Code:
 
TAR-T6690
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6690-10mg10mg£113.00
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TAR-T6690-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T6690-25mg25mg£136.00
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TAR-T6690-50mg50mg£152.00
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TAR-T6690-100mg100mg£198.00
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TAR-T6690-200mg200mg£237.00
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Further Information

Bioactivity:
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
CAS:
293754-55-9
Formula:
C17H12F9NO3S
Molecular Weight:
481.33
Pathway:
Metabolism; Apoptosis
Purity:
0.9958
SMILES:
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Target:
Apoptosis; FXR; Liver X Receptor; ROR

References

Houck KA, et al. Mol Genet Metab, 2004, 83(1-2), 184-187. Kumar N, et al. Mol Pharmacol, 2010, 77(2), 228-236. Liu N, Sun Q, Xu H, et al. Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver[J]. The FASEB Journal. 2020, 34(10): 13474-13493. Li C, Wu H, Na H S T, et al. Neuronal-Microglial Liver X receptor ? Activating Decrease Neuroinflammation and Chronic Stress-induced Depression-Related Behavior in Mice. Brain Research. 2022: 148112. Repa JJ, et al. Science, 2000, 289(5484), 1524-1529. Koldamova RP, et al. J Biol Chem, 2005, 280(6), 4079-4088. Mitro N, et al. FEBS Lett, 2007, 581(9), 1721-1726. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor ?B. Mol Med Rep. 2016 Jun;13(6):4888-96